I am excited to share our most recent work looking at the ciliary base of mammalian multiciliated cells w/ cryo-ET, XL/MS, and U-ExM. Using subtomogram averaging and classification, we mapped out structural changes along the microtubules of the ciliary base, highlighting densities specific to each region. To supplement our cryo-ET, we built a mammalian multiciliated […]
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New Preprint: The CAGE Complex
I am excited to share our new preprint on the CAGE complex, a mysterious hollow protein complex that I first saw years ago while surveying Tetrahymena ciliary lysate. We have renamed it to CAGE: Conserved Assembly in Gram-negative bacteria and Eukaryotes; because in addition to shape, it has crazy phylogeny!! And to quote the paper: […]
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