I am excited to share our most recent work looking at the ciliary base of mammalian multiciliated cells w/ cryo-ET, XL/MS, and U-ExM. Using subtomogram averaging and classification, we mapped out structural changes along the microtubules of the ciliary base, highlighting densities specific to each region. To supplement our cryo-ET, we built a mammalian multiciliated […]
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New Preprint: The CAGE Complex
I am excited to share our new preprint on the CAGE complex, a mysterious hollow protein complex that I first saw years ago while surveying Tetrahymena ciliary lysate. We have renamed it to CAGE: Conserved Assembly in Gram-negative bacteria and Eukaryotes; because in addition to shape, it has crazy phylogeny!! And to quote the paper: […]
Read MoreStructural Biology Block Course 2025
That’s a wrap on the computational week of this year’s Biozentrum Structural Biology Block Course! Like last year, students used AlphaFold to predict the structures of novel proteins and presented them to the class. Now, they’ll head into the lab for a few weeks with members of Biozentrum structural biology labs and analyze their proteins. […]
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